Microneedle Patch Delivers Oxygen to Chronic Wounds

microneedle-patch-delivers-oxygen-to-chronic-wounds




Purdue University scientists developed a microneedle patch that can supply oxygen and antimicrobials to chronic wounds.

Bacterial biofilms that grow on non-healing lesions, such as foot ulcers, create a difficult barrier to therapy.

Hypoxic wounds are common, and bacteria within them are protected from antibiotics by the biofilm structure. This new method is intended to deliver calcium peroxide to biofilms in a non-invasive manner, resulting in antibacterial activity and oxygen generation within the wound.

Chronic wounds are a major cause of suffering and impairment around the world. Certain patient populations, such as those with diabetes, are more prone to developing such wounds, which can be difficult to treat once they have developed. Such wounds can worsen if treatment is poor or delayed, potentially leading to sepsis and/or limb amputation. Antimicrobial therapies, whether delivered externally or systemically, can be protected by a sticky biofilm layer formed by bacteria within such wounds.

Microneedle Patch Delivers Oxygen To Chronic Wounds

Microneedle Patch Delivers Oxygen to Chronic Wounds

This microneedle technology is intended to break through biofilm and deliver treatments directly to the affected site. The biofilm functions as a shield, preventing antibiotics from accessing infected cells and tissues, according to Rahim Rahimi, a study researcher. “When these microneedles puncture the shield, they absorb and dissolve the fluid underneath, delivering the antibiotic straight to the ulcerated cells and tissues.”

Currently, debridement is used to remove the biofilm layer from such wounds. This, however, can be extremely uncomfortable and can potentially cause harm to healthy tissue. Because the microneedles aren’t long enough to touch nerve endings in the foot, they don’t produce pain, according to Rahimi. “The team evaluated the microneedles on ex vivo porcine wound models in this published study. The microneedles disintegrated in less than five minutes, the antibiotic was given, and the patch was removed.”

The patch is made up of a series of dissolvable needles that transport calcium peroxide to the wound, increasing tissue oxygenation levels. This makes the wound more hostile to anaerobic bacteria, as well as improving tissue health, as inadequate blood flow is a common cause of wound genesis and progression.

The patch has so far been tested in swine tissue samples, and the researchers have discovered that it can kill bacteria that cause wound biofilms, as well as causing very little cell death in human cells, indicating that it is cytocompatible.

Via: Purdue




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