FRIDAY, June 9, 2017 — Only one dose of an experimental Zika vaccine supplied mice with 100 p.c safety towards a doubtlessly deadly dose of the virus, researchers report.
The fast unfold of the Zika virus and its devastating results on the mind growth of infants have made the necessity for a vaccine to guard towards this mosquito-borne virus a world situation. At present, the principle technique to thrust back the virus is to keep away from mosquito bites.
The vaccine depends on know-how beforehand used to create experimental vaccines for HIV and Ebola virus. It was developed by GeoVax, an organization specializing in vaccines based mostly in Atlanta. Assessments of the vaccine have been achieved on the U.S. Facilities for Illness Management and Prevention in Colorado, with funding by a grant from the CDC.
The brand new vaccine targets a particular Zika virus protein referred to as NS1. This protein interferes with the mosquito immune system, which permits the virus to copy.
“A vaccine that may induce efficient antibodies to NS1 and disable its perform has the potential to scale back progress and transmission of Zika virus in its mosquito vector,” stated Farshad Guirakhoo, chief scientific officer at GeoVax.
For the research, researchers gave in any other case wholesome mice a excessive dose of the Zika virus. The virus was administered on to the rodents’ brains.
“A single dose of GeoVax’s NS1 vaccine candidate protected 100 p.c of vaccinated animals,” Guirakhoo stated in an American Society for Microbiology launch.
Mice in a management group got a placebo vaccine. They have been then given the virus. As much as 90 p.c died in about one week, the researchers reported.
Though the vaccine’s efficiency in mice appeared promising, analysis in animals does not at all times prove as effectively in people.
The research’s findings have been offered final week on the annual assembly of the American Society for Microbiology, in New Orleans. Findings offered at conferences are usually seen as preliminary till they have been revealed in a peer-reviewed journal.
The U.S. Facilities for Illness Management and Prevention offers extra info on Zika virus.
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