CHICAGO (AP) — Trendy contraception capsules which can be decrease in estrogen have fewer unwanted side effects than previous oral contraceptives. However a big Danish examine means that, like older capsules, they nonetheless modestly increase the chance of breast most cancers, particularly with long-term use.
Researchers discovered an analogous breast most cancers threat with the progestin-only intrauterine system, they usually couldn’t rule out a threat for different hormonal contraceptives just like the patch and the implant.
However the general elevated threat was small, amounting to 1 additional case of breast most cancers amongst 7,700 girls utilizing such contraceptives per yr. Specialists who reviewed the analysis say girls ought to steadiness the information towards recognized advantages of the capsule — together with reducing the chance of different cancers.
“Hormonal contraception ought to nonetheless be perceived as a secure and efficient choice for household planning,” mentioned Dr. JoAnn Manson, chief of preventive drugs at Harvard’s Brigham and Girls’s Hospital, who was not concerned within the analysis.
Girls of their 40s might need to contemplate non-hormonal IUDs, getting their tubes tied or speaking with their companions about vasectomy, Manson mentioned.
Research of older contraception capsules have proven “a internet most cancers profit” due to lowered threat of most cancers of the colon, uterus and ovaries regardless of a raised breast most cancers threat, mentioned Mia Gaudet, a breast most cancers epidemiologist on the American Most cancers Society.
There was optimism that newer, low-dose contraceptives would decrease the breast most cancers threat, however these outcomes have dashed these hopes, mentioned Gaudet, who wasn’t concerned within the analysis.
About 140 million girls use some sort of hormonal contraception, together with about 16 million in the US.
Researchers analyzed well being information of 1.eight million girls, ages 15 to 49, in Denmark the place a nationwide well being care system permits linking up massive databases of prescription histories, most cancers diagnoses and different data.
Outcomes had been printed Wednesday within the New England Journal of Medication. Novo Nordisk Basis funded the analysis, however performed no position in designing the examine. The muse has ties to the Danish pharmaceutical firm Novo Nordisk, which primarily makes diabetes medication and doesn’t make contraceptives.
Present and up to date use of hormonal contraceptives was related to a 20 % elevated threat of breast most cancers. Threat elevated with longer use, from a 9 % improve in threat with lower than a yr of contraceptive use to a 38 % improve after greater than 10 years of use.
Digging additional, the researchers discovered no variations amongst forms of contraception capsules. Due to fewer customers, the outcomes for the patch, vaginal ring, implant and progestin shot had been much less clear, however the evaluation didn’t rule out an elevated breast most cancers threat for these strategies.
“No sort of hormone contraceptive is risk-free sadly,” mentioned lead writer Lina Morch of Copenhagen College Hospital.
Researchers accounted for schooling, childbirth and household historical past of breast most cancers, however they weren’t in a position to regulate for a number of different recognized most cancers threat components corresponding to alcohol use and restricted bodily exercise, or protecting components corresponding to breast-feeding.
Girls with a household historical past of breast most cancers might need to ask their medical doctors about different contraceptives, mentioned Dr. Roshni Rao, a breast surgeon at New York-Presbyterian/Columbia College Medical Middle.
“Oral contraceptives are like another treatment,” Rao mentioned. “There are dangers and there are advantages. When you have a purpose to be taking them, it’s completely cheap to take action.”
Comply with AP Medical Author Carla Okay. Johnson on Twitter: @CarlaKJohnson